"People had theoretically showed it could be done, but no one thought the instrument was practical. Theory showed that if you had enough electrons hitting a specimen to achieve the magnification you needed, you would burn the specimen."
"I believe that you have to take some intelligent risks to advance science."
"every graduate student is an individual and everybody has a different way of doing science, approaching science"
"As many of his colleagues can attest, the wave nature of the electron was no remote or discouragingly abstract conception to him. Peering at the viewing screen while he manipulated the controls of an electron microscope, he could be seen to be thinking in terms of wave functions. "
"I didn't know enough diffraction theory to even know why what I was doing wouldn't work. That was a problem. I was too much of an empiricist at the time. I learned later that it's better to know what you are doing."
"... fluorescence microscopy in its early years was considered a specialized method which, in the opinion of some, was doomed to fail. "
"We were bombarded — this is the best way to put it — by requests from all the medical people and all the colloidal physics people — everybody that had things too small to be seen in a light microscope. We quickly realized that two graduate students working in a makeshift lab with a makeshift instrument couldn't satisfy the needs for this tool. "