ORNL microscopy directly images lithium dendrites in batteries Learn more...
Microscopy Products, News, Events and Resources
Is a resolution of 0. 1 Å for electron microscopes possible and if so is it a goal worthy of pursuit. Stephen Pennycook and Sergei Kalinin weigh in on this question Microscopy: Hasten high resolution. Learn more... Image: Wu Zhou/Oak Ridge Natl Lab
Multi-layer Laue lens module inside the vacuum chamber of the microscope installed at the Hard X-ray Nanoprobe beamline at NSLS-II. Learn more...
Using cryo-electron microscopy researchers at Berkeley Labs captured images of bacteria that are at the lower size limit for life. Learn more...
Obtaining EBSD patterns from 10 nanometer crystals can be done with modifications to standard SEM EBSD systems. Learn more... Image: Roy Geiss, NIST
A new technique using stimulated Raman scattering (SRS) microscopy and metabolic labeling images new synthesized protein in live cells. Learn more... Lu Wei of Columbia University
Barnacle appendages. Confocal microscopy, Igor Siwanowicz, HHMI Janelia Research Campus. One of many stunning images from the galleries from the Olympus BioScapes Digital Imaging Competition®. Learn more...
SCAPE High-Speed 3D Microscope imaging of the living brain, with green GCaMP labeling apical dendrites of layer 5 neurons, and red showing Texas red dextran in the vasculature. Learn more... Image: Elizabeth Hillman and Clay Lacefield
Our mission is to find the most interesting news on advancements in microscope instrumentation and the discoveries made using microscopy to you. News from academic and government research labs, manufacturers, and societies are included.
Research and Innovations
Transient Absorption (TA) Microscopy couples ultrafast temporal resolution with high spatial resolution to obtain information on heterogeneous electronic properties across domains ranging from tens to hundreds of nanometers in size of organic photovoltaic films. The technique measures changes in adsorption spectra resulting from femtosecond laser pulses that have excited the transient energy states.
John Miao, a UCLA professor, and his colleagues have contributed an article to the May 2015 issue of Science, in which they review and analyze the wide range of applications that have stemmed from Miao's technique of coherent diffractive imaging (CDI). Developed in 1999, CDI uses an X-ray and a computational algorithm to interpret the diffraction pattern, instead of a lens. This allows users to achieve high-resolution, high-contrast imaging of nanoscale objects, and was the first method in X-ray crystallography to enable imaging of noncrystalline materials and nanocrystals.
The National Physical Laboratory (NPL) has developed a microscopic specimen that features single-nanometer spacings. These protein nanostructures would make an excellent material for calibration standards. EM users would be able to calibrate with greater reproducibility, accuracy, traceability and precision.
The Korea Advanced Institute of Science and Technology (KAIST) has published an article in Optics Express, the journal of the The Optical Society detailing a new microscope technique to identify bacteria more quickly. This simple modification to a traditional microscope could help in medical applications by eliminating the need to culture microbes prior to identification, and in food services applications to identify any pathogens. It works by using laser holographic techniques to identify single bacterial species, and uses mathematical and computer software with a machine-learning algorithm that is similar to that used for facial recognition in security cameras.
Product and Company
Scientists can now deposit multiple samples onto one SEM/TEM support with the sciTEM from SCIENION. Experiments that were previously impractical because of the time and financial expense required will now become possible. In applications such as quality control, where a high number of samples or groups of samples need to be analyzed, the sciTEM will enable more cost-effective, high-throughput TEM. The SciTEM has already been utilized in Liquid Cell Transmission Electron Microscopy by researchers and professors at the University of California, San Diego.
As of June 1 2015 the Olympus Soft Imaging Solutions (OSIS) GmbH EMIC product group will be taken over by EMSIS GmbH, a new start-up with decades of experience in electron microscopy.
The new NordlysMax3 electron back scatter detector from Oxford Instruments has almost double the rate of aquisition over the previous model.
The super-resolution K2 Summit camera for cryo-electron microscopy uses electron counting to record the highest resolution images with the lowest noise. This technology has enabled researchers to determine protein structures at 2.8 Å resolution and protective antigen pore structure at 2.9 Å resolution using single particle cryo-EM.
Quotes / About Microscopy and From Microscopists
"We were bombarded — this is the best way to put it — by requests from all the medical people and all the colloidal physics people — everybody that had things too small to be seen in a light microscope. We quickly realized that two graduate students working in a makeshift lab with a makeshift instrument couldn't satisfy the needs for this tool. "
"Roger, at Cornell University they have an incredible piece of scientific equipment known as the Tunneling Electron Microscope. Now, this microscope is so powerful that by firing electrons you can actually see images of the atom, the infinitesimally minute building blocks of our universe. Roger, if I were using that microscope right now, I still wouldn't be able to locate my interest in your problem. "
"Once you add a computer between the microscope and the human observer, the whole game changes. At that point a microscope is no longer a device that has to generate a directly interpretable image. Now it's a device to record information."
"People had theoretically showed it could be done, but no one thought the instrument was practical. Theory showed that if you had enough electrons hitting a specimen to achieve the magnification you needed, you would burn the specimen."