ORNL microscopy directly images lithium dendrites in batteries Learn more...
Microscopy Products, News, Events and Resources
Is a resolution of 0. 1 Å for electron microscopes possible and if so is it a goal worthy of pursuit. Stephen Pennycook and Sergei Kalinin weigh in on this question Microscopy: Hasten high resolution. Learn more... Image: Wu Zhou/Oak Ridge Natl Lab
Multi-layer Laue lens module inside the vacuum chamber of the microscope installed at the Hard X-ray Nanoprobe beamline at NSLS-II. Learn more...
Using cryo-electron microscopy researchers at Berkeley Labs captured images of bacteria that are at the lower size limit for life. Learn more...
Obtaining EBSD patterns from 10 nanometer crystals can be done with modifications to standard SEM EBSD systems. Learn more... Image: Roy Geiss, NIST
A new technique using stimulated Raman scattering (SRS) microscopy and metabolic labeling images new synthesized protein in live cells. Learn more... Lu Wei of Columbia University
Barnacle appendages. Confocal microscopy, Igor Siwanowicz, HHMI Janelia Research Campus. One of many stunning images from the galleries from the Olympus BioScapes Digital Imaging Competition®. Learn more...
SCAPE High-Speed 3D Microscope imaging of the living brain, with green GCaMP labeling apical dendrites of layer 5 neurons, and red showing Texas red dextran in the vasculature. Learn more... Image: Elizabeth Hillman and Clay Lacefield
Our mission is to find the most interesting news on advancements in microscope instrumentation and the discoveries made using microscopy to you. News from academic and government research labs, manufacturers, and societies are included.
Research and Innovations
Transient Absorption (TA) Microscopy couples ultrafast temporal resolution with high spatial resolution to obtain information on heterogeneous electronic properties across domains ranging from tens to hundreds of nanometers in size of organic photovoltaic films. The technique measures changes in adsorption spectra resulting from femtosecond laser pulses that have excited the transient energy states.
John Miao, a UCLA professor, and his colleagues have contributed an article to the May 2015 issue of Science, in which they review and analyze the wide range of applications that have stemmed from Miao's technique of coherent diffractive imaging (CDI). Developed in 1999, CDI uses an X-ray and a computational algorithm to interpret the diffraction pattern, instead of a lens. This allows users to achieve high-resolution, high-contrast imaging of nanoscale objects, and was the first method in X-ray crystallography to enable imaging of noncrystalline materials and nanocrystals.
The National Physical Laboratory (NPL) has developed a microscopic specimen that features single-nanometer spacings. These protein nanostructures would make an excellent material for calibration standards. EM users would be able to calibrate with greater reproducibility, accuracy, traceability and precision.
Naomi Ginsberg, a chemist at Berkeley Lab, is leading the development of CLAIRE (short for "cathodoluminescence activated imaging by resonant energy transfer"). This modality is a non-invasive means for obtaining images of soft matter, and is less destructive of materials than traditional EM methods. CLAIRE uses an electron beam to pass through scintillating film and hit the sample, then creates an image from the luminescence emitted by the sample. Ginsberg states the group is hopeful CLAIRE will be useful in more applications, like watching crystallization or processes in membrane biophysics.
Product and Company
As of June 1 2015 the Olympus Soft Imaging Solutions (OSIS) GmbH EMIC product group will be taken over by EMSIS GmbH, a new start-up with decades of experience in electron microscopy.
The new NordlysMax3 electron back scatter detector from Oxford Instruments has almost double the rate of aquisition over the previous model.
The super-resolution K2 Summit camera for cryo-electron microscopy uses electron counting to record the highest resolution images with the lowest noise. This technology has enabled researchers to determine protein structures at 2.8 Å resolution and protective antigen pore structure at 2.9 Å resolution using single particle cryo-EM.
TESCAN has introduced a coherence-controlled holographic microscope for quantitative phase imaging of biological specimen. This expands Tescan's product line into the advanced light microscopy.
Quotes / About Microscopy and From Microscopists
"I would like to try and impress upon you while I am talking about all of these things on a small scale, the importance of improving the electron microscope by a hundred times. It is not impossible; it is not against the laws of diffraction of the electron. The wave length of the electron in such a microscope is only 1/20 of an angstrom. So it should be possible to see the individual atoms. "
"'What are you going to do as a graduate student?' He just assumed that I was going to be one. He started talking about the electron microscope. I had never heard of such an animal, so it intrigued me. I guess within hours I decided to look at the electron microscopes as a career. "
"It took me about twenty years before I had the right system that could be realized in practice and that scientist said it could work"
"I thought that if I patented it, no one else would be able to do work with it. I might earn some money, but I was not interested in that. I was interested in applications for many researchers, creating more fundamental science. So I decided not to patent it."